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It causes physical symptoms and can cause lasting damage to the body because of both direct effects and indirect complications of living with this mental illness. Depression can cause some areas of the brain to shrink and the damage can last even when the disease has stopped. Pin On Montgomery News Headline They think genetics. . But now it is proven that brain damage does not cause depression but quite the opposite. When you think of clinical depression you probably think of feeling sad and down for long periods of time. Does Depression Cause Brain Damage. But besides these depression can actually change your ability to. When comparing the healthy control brains to those that had experienced regular episodes of depression he could reasonably conclude that depression actually does tangible physical damage to the brain. Thats according to a first-of-its-kind study showing evidence of lasting biological changes in the. We ex...